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Computational Techniques for Protein 3D Structure Prediction

Learn how to Predict Protein 3D Structure using Computational Tools for Drug Discovery and more.

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Updated August 13, 2026

What you'll learn

Understand the fundamental principles of protein structure prediction.
Gain hands-on experience with leading computational tools such as MODELLER, Swiss-Model, I-TASSER, and AlphaFold.
Learn how to select appropriate templates, perform sequence alignment, and refine protein models for accuracy.
Explore advanced modeling options, model quality assessment techniques, and confidence score estimation methods.
Discover the applications of protein structure prediction in drug discovery, molecular biology, and protein engineering.
Stay updated with emerging trends and technologies in the field of computational bioinformatics.
Apply your newfound knowledge and skills to real-world research projects.

Course Syllabus

Description

Welcome to "Computational Techniques for Protein 3D Structure Prediction," a cutting-edge course designed to equip you with the skills and knowledge needed to excel in the field of bioinformatics. If you're fascinated by the proteins and eager to explore the power of computational techniques in predicting their 3D structures, this course is for you.

In this course, we'll talk about the protein structure prediction, where you'll learn how to leverage advanced computational tools to predict the 3D structure of proteins form protein sequences. Through a series of engaging lectures and hands-on exercises, you'll gain a deep understanding of the fundamental principles, methodologies, and applications of protein structure prediction.

We'll kick off our journey with an insightful introduction, laying the groundwork by exploring the importance and challenges of protein structure prediction. From there, we'll dive into the practical aspects, we got four key sections:

  1. Protein Structure Prediction Via MODELLER: Discover the power of MODELLER, a versatile software tool for homology modeling. Learn how to select appropriate templates, predict the proteins structure, and refine models to achieve accurate predictions.

  2. Protein Structure Prediction Via Swiss-Model: Learn about the capabilities of Swiss-Model, an automated modeling platform renowned for its efficiency and reliability. Explore its features for automated modeling, advanced options, and model quality assessment.

  3. Protein Structure Prediction Via I-TASSER: Explore the innovative approaches of I-TASSER, blending threading and ab initio modeling techniques for comprehensive structure prediction. We'll be talking about, obviously the  structure prediction Via I-TASSER, model refinement, confidence score estimation, and comparative analysis.

  4. Protein Structure Prediction Via AlphaFold (Machine Learning): Experience the future of protein structure prediction with AlphaFold, a groundbreaking deep learning algorithm. Understand its training data, model architecture, accuracy evaluation, and future applications.

Throughout the course, you'll not only learn the theoretical foundations but also gain practical skills through hands-on exercises, case studies, and real-world examples. Whether you're a seasoned bioinformatics researcher or a curious beginner, this course will empower you to master the art of protein structure prediction and unlock new opportunities in drug discovery, molecular biology, and beyond.

Join us on this exciting journey and become a proficient practitioner in the dynamic field of computational bioinformatics.

Enroll now! and take the first step towards mastering protein structure prediction!

Requirements

  • Basic knowledge of bioinformatics and protein biology concepts.
  • Access to a computer with internet connectivity.
  • Familiarity with basic computational concepts in Bioinformatics(preferred but not required).
  • Willingness to learn and engage in hands-on exercises.

Instructor

Shahroz Rahman

Shahroz Rahman

Bioinformatics and Computational Biology Instructor

4.9Instructor rating · 2 courses

A bioinformatics enthusiast. Armed with a higher education degree in bioinformatics, I am passionate about decoding the secrets of life through computational biology. Join me on OmicSkills as I simplify the complexities of bioinformatics, guiding you through genomics, proteomics, and the exciting world where biology meets algorithms. Let's explore the wonders of this field together!

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